A motorist suffered a serious head injury after a car overturned in a crash involving a lorry and four vehicles on the M62 on Merseyside.
The man, in his 50s, was taken to the major trauma centre at Aintree University Hospital after crash near junction 5 for Huyton at 07:30 BST.
One car flipped on its roof, the lorry straddled the carriageway and a wrecked car was left on the hard shoulder.
The M62 was closed westbound causing huge rush-hour delays.
Two other people were hurt in the multi-vehicle crash, said North West Ambulance Service.
A man in his 30s suffered a shoulder injury while a woman in her 40s was also treated in hospital.
One person who was trapped inside a car was freed by firefighters.
North West Motorway Police said the crash affected rush-hour traffic with all lanes westbound into Liverpool blocked.
The carriageway reopened after being closed for five hours.